AMA Series : We ’ re researchers at the NNF

Hello Reddit! We are Ida Donkin, Soetkin Versteyhe, Lars R. Ingerslev, and Romain Barrès from the Novo Nordisk Foundation Center for Basic Metabolic Research. We recently published a study that shows that sperm from obese men carry a distinct epigenetic signature compared to lean men, in particular at genes controlling brain development and function. In addition, we also looked at gastric bypass patients before and after surgery, and found that the sperm methylome is remodeled notably at gene regions implicated in the central control of appetite. Please Ask Us Anything! We will start answering questions at 1 pm EST (19:00 CET). EDIT 3.20 PM EST: Thank you so much for all the great questions! We’re signing off now, but we’ll check in again tomorrow for a few follow-up questions. Again, thanks guys! ANOTHER EDIT: The story behind the AMA here: http://www.museion.ku.dk/2015/12/reddit-science-ama/ Links: The actual paper: http://www.cell.com/pb-assets/journals/research/cell-metabolism/on/cmet1935_r.pdf NY Times http://www.nytimes.com/2015/12/08/science/parents-may-pass-down-more-than-just-genes-study-suggests.html The Guardian http://www.theguardian.com/science/2015/dec/03/overweight-men-may-pass-genetic-obesity-risk-to-their-children Our research group: http://metabol.ku.dk/research/section-for-integrative-physiology/environmental-epigenetics/